is it possible to correlate the creatine kinase level to the extenet of tissue damage?

Question

is it possible to correlate the creatine kinase level to the extenet of tissue damage?

Answer 1

Hello...I am assuming you mean cardiac tissue damage. Creatinine kinase has a direct relationship with tissue damage. That means, that the more it is elevated, the more damage has occurred. There is no exact correlation and to make things more complicated the time of the blood draw with respect to the presumed onset of the damaging event also plays a role. Creatinine kinase, though, is no longer considered a good test for testing heart tissue damage (it is used to test for skeletal muscle damage...it will always go up after a good work out). The tests used currently are "troponin" and "CK-MB" (or creatinine kinase-myocardial fraction). These are far more specific for heart damage, and again are directly correlated with the amount of injury.



Specific timing of enzyme elevation:



CK (and CK-MB) -- starts rising at about 4-6 hours.

Peaks at 12-24 hours. Disappears at 3-4 days.



Troponins -- start rising at about 4-6 hours.

Peak at about 24 hours. Disappear at 7-10 days.



This is illustrated on this graph I just found: http://www.acc.org/clinical/consensus/mi_redefined/tables.htm#fig1.



(Scroll down to figure 2)





Hope that helps!

Answer 2

creatinine kinase is present in muscles in the body and even in the brain.

it has three subtypes:

CK-MB found in heart

CK-MM found in all muscles

CK-BB found in brain



any injury especially to muscles elevates the Creatinine Kinase level,but there is no specific correlation between the quantity of Creatinine and the extent of the injury...

another thing,it is useless in medicine,cause i dont care about the severity of the injury especially for the heart muscle,,,,in fact i only care about the elevation by itself,because it tells me that there is an injury and this is only what makes the importance.

elevation of CK-MB means heart attack,this is what i should waste my time on managing,not the amount of increase.